Pizza Express have announced they could be closing 15% of their UK restaurants with over 1,000 jobs at risk.
The chain currently have four outlets in Milton Keynes - at The Centre MK, The Hub, Xscape and MK1.
It is not known if any of these four outlets will be included in the closure list.
Andy Pellington, group chief finance officer at Pizza Express, said: "While we have had to make some very difficult decisions, none of which has been taken lightly, we are confident in the actions being taken to reduce the level of debt, create a more focused business and improve the operational performance, all of which puts us in a much stronger position.
"We can now plan to invest in both our UK&I and international businesses as well as support our teams as they return to work."
Zoe Bowley, UK and Ireland managing director at Pizza Express, said: "Our business has a long history of success, but the UK-wide lockdown has hit the hospitality industry particularly hard.
"While the financial restructuring is a positive step forward, at the same time we have had to make some really tough decisions.
"As a result, it is with a heavy heart that we expect to permanently close a proportion of our restaurants, losing valued team members in the process."