In a note in the store's window, the staff thanked their loyal customers over the years and said that they would be missed.
The Milton Keynes branch has now been completely packed up and emptied after ASOS purchased Topshop, Topman and Miss Selfridge at the beginning of the month.
While the three brands will be available still online at ASOS, all 70 stores were not part of the deal, leaving around 2,500 staff without a job.
The staff at the Milton Keynes store spent their final days of working for the company packing up clothes to be sent to ASOS to be sold online.
They did not want to leave without saying goodbye though, leaving this note on the window for customers.
The closure of Topshop/Topman in Intu Milton Keynes comes after the closure of the Outfit store, part of Arcadia group, at MK1 Bletchley last year.
