The A509 between Osier Way and Warrington Farm will be closed for 3 weeks from Monday 15 November.
It is scheduled to be reopened on 4th December.
MK Council said: "Essential works are taking place during this closure and to reduce further disruption to road users, our Streetworks team have co-ordinated with several companies to include works to be done under the one road closure."
These works will include:
- Gas mains works
- Electrical works including 2 miles streetlighting cabling by Western Power Distribution
- Sewerage and drainage works by Anglian Water
- S278 developer works for a new junction, Redway and footway
The alternative route will be via A428 Bedford Road, A428 Northampton Road, A422 Newport Pagnell Road, Newport Road, A509, High Street and Wellingborough Road (and vice versa).
Details of the closure may be viewed here.