Final proposals for new parliamentary constituencies from Boundary Commission England will see Stony Stratford and Wolverton move into the Buckingham constituency, if approved by parliament.
The plans set out how the number of parliamentary constituencies should be reduced from 650 to 600, first agreed under the coalition government in 2011.
The new proposals will see both the Milton Keynes North and South constituencies shrunk in terms of area to reflect the increased population since the boundaries were last drawn.
But in a controversial move, the areas of Wolverton, Crownhill, Stony Stratford, Greenleys, Old Wolverton, New Bradwell, Blue Bridge and Bancroft Park move into the Buckingham constituency.
The seat will be renamed 'Buckingham and Milton Keynes West' under the plans.
It will see these areas as part of a giant single rural constituency, incorporating Buckingham in the centre and going as far as Edgcott (near Bicester) to the west and Princes Risborough (near High Wycombe) in the south.
Buckingham is currently served by John Bercow MP, the speaker of the House of Commons.
The new Milton Keynes South will comprise of an 'L' shape starting in Great Linford and Neath Hill, moving through Stantonbury, Bradwell, Kiln Farm to Two Mile Ash and then along to Loughton, Shenley Church End, Westcroft, Tattenhoe, Furzton and Bletchley.
Milton Keynes North East will contain Olney, Newport Pagnell and the northern villages, as well as the area north of the A5 between Rooksley and the Train Station, down towards Bow Brickhill. All estates between the A5 and the M1 will be part of this area, including Eaglestone, Middleton, Northfield, Kents Hill, Walnut Tree and Willen.
Following the publication of the commissions' final proposals, the government will now have to decide when to bring the plans to a parliamentary vote.
