The incident occurred at around 1.15pm on Saturday (25/5) on Chaffron Way at the junction with Strudwick Drive, Oldbrook.
A silver Lexus IS300 car and a silver Honda moped were involved in the collision.
A man in his fifties sustained serious injuries in the incident and remains in hospital.
Investigating officer, PC Richard Minney, of the Joint Roads Policing unit said: “I am appealing for witnesses to this collision whereby a man has sustained serious injuries as a result.
“I would ask for anyone who was in or near the area in which this collision took place to get in touch with us if you saw the incident or anything leading up to it.
“Also, if any motorists in the area have dash-cams, please check the footage in case anything significant was caught as it could help our investigation.
“You can contact police by calling the 24-hour non-emergency number 101, quoting reference number 43240244329, or by making a report online.”
